A comparison of the effect of viscosity on the precorneal residence of solutions in rabbit and man

J Pharm Pharmacol. 1986 Jun;38(6):463-6. doi: 10.1111/j.2042-7158.1986.tb04611.x.


The precorneal drainage of radiolabelled solutions containing polyvinyl alcohol (PVA) or hydroxypropyl methylcellulose (HPMC) have been measured in rabbit and man by gamma scintigraphy. Concentration of the polymers was varied to produce solutions with a viscosity range between 10.2 and 102 mPas. Solution drainage was faster in man than in the rabbit with a more pronounced effect of viscosity. Significant retardation of drainage in man was noted at the higher polymer concentrations (0.9% HPMC or 5.85% PVA).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Female
  • Humans
  • Hypromellose Derivatives
  • Male
  • Methylcellulose / analogs & derivatives
  • Ophthalmic Solutions / metabolism*
  • Polyvinyl Alcohol
  • Rabbits
  • Species Specificity
  • Viscosity


  • Ophthalmic Solutions
  • Hypromellose Derivatives
  • Polyvinyl Alcohol
  • Methylcellulose