Successful treatment of metastatic clear cell carcinoma with nivolumab in a patient receiving dialysis treatment

Int J Urol. 2017 Sep;24(9):708-710. doi: 10.1111/iju.13420. Epub 2017 Jul 21.

Abstract

The efficacy and safety of nivolumab for patients receiving dialysis treatment has not been established yet. Herein, we describe a patient on dialysis successfully treated with nivolumab as seventh-line therapy for metastatic renal cell carcinoma. Before initiating nivolumab, he had respiratory discomfort induced by a lesion occluding the left intermediate bronchus that originated from the metastatic lymph node behind the tracheal bifurcation. Four weeks after nivolumab was initiated, his symptom remarkably improved, and the occlusion disappeared according to the bronchoscopy examination. The effectiveness and safety of nivolumab has continued for 6 months. There are few cases in which nivolumab has been given to patients on dialysis. In the present case, nivolumab was given to a patient on dialysis, and it resulted in a remarkable improvement without any adverse events.

Keywords: carcinoma; dialysis; nivolumab; renal cell carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Immunological / therapeutic use*
  • Carcinoma, Renal Cell / diagnostic imaging
  • Carcinoma, Renal Cell / secondary
  • Carcinoma, Renal Cell / therapy*
  • Humans
  • Kidney Neoplasms / diagnostic imaging
  • Kidney Neoplasms / pathology
  • Kidney Neoplasms / therapy*
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / secondary
  • Lung Neoplasms / therapy*
  • Male
  • Middle Aged
  • Nephrectomy
  • Nivolumab / therapeutic use*
  • Renal Dialysis*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Antineoplastic Agents, Immunological
  • Nivolumab