CD8+ T cell programming by cytomegalovirus vectors: applications in prophylactic and therapeutic vaccination

Curr Opin Immunol. 2017 Aug;47:52-56. doi: 10.1016/j.coi.2017.06.010. Epub 2017 Jul 19.

Abstract

Vectors based on cytomegalovirus (CMV) represent a novel vaccine platform that maintains high frequencies of non-exhausted effector memory T cells in both CMV sero-positive and sero-negative individuals. In non-human primate models, CMV vectored vaccines provide unprecedented protection against simian immunodeficiency virus (SIV). Moreover, CMV vectors can be genetically altered to program highly diverse CD8+ T cell responses that differ in their epitope targeting including conventional, MHC-I restricted CD8+ T cells as well as unconventional CD8+ T cells restricted by MHC class II or non-polymorphic MHC-E. By modifying cytomegaloviral determinants that control unconventional T cell priming it is possible to uniquely tailor the CD8+ T cell response for each individual disease target in order to maximize prophylactic or therapeutic protection.

Publication types

  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / physiology*
  • Cytomegalovirus / genetics*
  • Epitopes, T-Lymphocyte / genetics*
  • Genetic Vectors / genetics*
  • Humans
  • Vaccination
  • Vaccines / immunology*
  • Viral Proteins / genetics*

Substances

  • Epitopes, T-Lymphocyte
  • Vaccines
  • Viral Proteins