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Review
. 2017 Nov;33(11):875-888.
doi: 10.1016/j.pt.2017.06.011. Epub 2017 Jul 19.

Exploiting Helminth-Host Interactomes Through Big Data

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Review

Exploiting Helminth-Host Interactomes Through Big Data

Javier Sotillo et al. Trends Parasitol. .

Abstract

Helminths facilitate their parasitic existence through the production and secretion of different molecules, including proteins. Some helminth proteins can manipulate the host's immune system, a phenomenon that is now being exploited with a view to developing therapeutics for inflammatory diseases. In recent years, hundreds of helminth genomes have been sequenced, but as a community we are still taking baby steps when it comes to identifying proteins that govern host-helminth interactions. The information generated from genomic, immunomic, and proteomic studies, as well as from cutting-edge approaches such as proteogenomics, is leading to a substantial volume of big data that can be utilised to shed light on fundamental biology and provide solutions for the development of bioactive-molecule-based therapeutics.

Keywords: helminth; immunomodulator; pharmacopoeia; proteomics; secretome; vaccine.

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