Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial

Complement Ther Med. 2017 Aug;33:1-5. doi: 10.1016/j.ctim.2017.05.006. Epub 2017 May 29.

Abstract

Background: Type 2 diabetes (T2D) is an established risk factor for cardiovascular disease (CVD) and is associated with disturbed metabolism of lipids and lipoproteins. Curcuminoids are natural products with anti-diabetic and lipid-modifying actions but their efficacy in improving dyslipidemia in diabetic individuals has not been sufficiently studied.

Objective: To investigate the efficacy of supplementation with curcuminoids, plus piperine as an absorption enhancer, in improving serum lipids in patients with T2D.

Methods: In this 12-week randomized double-blind placebo-controlled trial, subjects with T2D (n=118) were assigned to curcuminoids (1000mg/day plus piperine 10mg/day) or placebo plus standard of care for T2D. Serum concentrations of lipids including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), lipoprotein(a) [Lp(a)], and non-HDL-C were determined at baseline and at the end of trial.

Results: Between-group comparison of change in the study parameters revealed significant reductions in serum levels of TC (-21.86±25.78 versus -17.06±41.51, respectively; p=0.023), non-HDL-C (-23.42±25.13 versus -16.84±41.42, respectively; p=0.014) and Lp(a) (-1.50±1.61 versus -0.34±1.73, respectively; p=0.001) and elevations in serum HDL-C levels (1.56±4.25 versus -0.22±4.62, respectively; p=0.048) in the curcuminoids group as compared with the placebo group (p<0.05). Serum TG and LDL-C changes did not show any significant difference between the study groups (p>0.05).

Conclusion: Curcuminoids supplementation can reduce serum levels of atherogenic lipid indices including non-HDL-C and Lp(a). Therefore, curcuminoids supplementation could contribute to a reduced risk of cardiovascular events in dyslipidemic patients with T2D.

Keywords: Cardiovascular disease; Cholesterol; Curcumin; Diabetes; Dyslipidemia; Lipoprotein(a).

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Alkaloids / pharmacology
  • Benzodioxoles / pharmacology
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Curcuma / chemistry*
  • Curcumin / pharmacology
  • Curcumin / therapeutic use*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications*
  • Dietary Supplements
  • Double-Blind Method
  • Dyslipidemias / blood
  • Dyslipidemias / complications
  • Dyslipidemias / drug therapy*
  • Female
  • Humans
  • Lipids / blood*
  • Lipoprotein(a) / blood
  • Male
  • Middle Aged
  • Phytotherapy*
  • Piperidines / pharmacology
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Polyunsaturated Alkamides / pharmacology
  • Triglycerides / blood

Substances

  • Alkaloids
  • Benzodioxoles
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Lipids
  • Lipoprotein(a)
  • Piperidines
  • Plant Extracts
  • Polyunsaturated Alkamides
  • Triglycerides
  • Cholesterol
  • Curcumin
  • piperine