Prevention and Treatment of the Post-Thrombotic Syndrome

Thromb Res. 2018 Apr;164:116-124. doi: 10.1016/j.thromres.2017.07.008. Epub 2017 Jul 15.

Abstract

Post-thrombotic syndrome (PTS) is a complication that develops in up to 50% of patients with deep vein thrombosis (DVT) and manifests as symptoms and signs of chronic venous insufficiency of varying severity. PTS negatively affects patient's quality of life and causes significant burden to the healthcare system. The risk for PTS development can be markedly reduced by preventing DVT and providing appropriate anticoagulation once it develops. Patients with extensive proximal (iliofemoral) DVT may benefit from invasive interventions, such as catheter-directed thrombolysis. The effectiveness of elastic compression stockings (ECS) for PTS prevention has not been conclusively demonstrated in randomized trials. Treatment of PTS is primarily based on ECS, exercise and lifestyle modifications. The effectiveness of various pharmacologic agents for PTS treatment remains controversial. Surgical or radiological interventions for vein reconstruction or revascularization may be considered in refractory cases. This review summarizes current evidence regarding prevention and treatment of PTS of the lower limbs in adults.

Keywords: Anticoagulation; Catheter-directed thrombolysis; Compression stocking; Deep vein thrombosis; Defibrotide; Hidrosmin; Post-thrombotic syndrome; Rutosides.

Publication types

  • Review

MeSH terms

  • Humans
  • Postthrombotic Syndrome / drug therapy*
  • Postthrombotic Syndrome / pathology
  • Postthrombotic Syndrome / prevention & control*
  • Venous Thrombosis / drug therapy*
  • Venous Thrombosis / pathology
  • Venous Thrombosis / prevention & control*