Short stature--physiology and pathology

West J Med. 1986 Jun;144(6):710-21.


Stature, the quantitative measure of height, varies widely within each ethnic group with a fairly normal distribution. Of the numerous patients whom physicians encounter because of short stature, relatively few are pathologically small in the context of family and ethnic background. Physicians must be able to differentiate pathologic short stature from the lower end of the normal curve before embarking on a complex diagnostic evaluation. There are literally hundreds of different causes of short stature, and the clinical evaluation requires a wide variety of clinical, radiographic, pathologic and biochemical tools. Although specific treatment to promote growth is available only in persons with the endocrinopathies and the acquired nutritional, emotional and chronic disease states, diagnosis of the specific form of short stature can have great importance in being able to prevent complications and to offer accurate prognostic information and genetic counseling.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Body Height*
  • Bone Diseases, Developmental / diagnosis
  • Child
  • Child, Preschool
  • Chromosome Aberrations / diagnosis
  • Chromosome Disorders
  • Dwarfism / diagnosis
  • Ethnic Groups
  • Female
  • Fetal Growth Retardation / diagnosis
  • Growth
  • Growth Disorders / diagnosis*
  • Growth Hormone / physiology
  • Growth Hormone-Releasing Hormone / physiology
  • Humans
  • Hypopituitarism / diagnosis
  • Male
  • Nutrition Disorders / diagnosis
  • Pregnancy
  • Reference Values
  • Somatomedins / physiology
  • Somatostatin / physiology


  • Somatomedins
  • Somatostatin
  • Growth Hormone
  • Growth Hormone-Releasing Hormone