Role of long non-coding RNAs in glucose metabolism in cancer

Chunmei Fan; Yanyan Tang; Jinpeng Wang; Fang Xiong; Can Guo; Yumin Wang; Shanshan Zhang; Zhaojian Gong; Fang Wei; Liting Yang; Yi He; Ming Zhou; Xiaoling Li; Guiyuan Li; Wei Xiong; Zhaoyang Zeng

doi:10.1186/s12943-017-0699-3

Role of long non-coding RNAs in glucose metabolism in cancer

Mol Cancer. 2017 Jul 24;16(1):130. doi: 10.1186/s12943-017-0699-3.

Authors

Chunmei Fan^{1

2

3}, Yanyan Tang², Jinpeng Wang², Fang Xiong¹, Can Guo², Yumin Wang^{1

2}, Shanshan Zhang¹, Zhaojian Gong², Fang Wei², Liting Yang², Yi He², Ming Zhou^{1

2

3}, Xiaoling Li^{1

2

3}, Guiyuan Li^{1

2

3}, Wei Xiong^{4

5

6}, Zhaoyang Zeng^{7

8

9}

Affiliations

¹ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁵ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁶ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁷ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.
⁸ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.
⁹ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.

Abstract

Long-noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides and do not code for proteins. However, this class of RNAs plays pivotal regulatory roles. The mechanism of their action is highly complex. Mounting evidence shows that lncRNAs can regulate cancer onset and progression in a variety of ways. They can not only regulate cancer cell proliferation, differentiation, invasion and metastasis, but can also regulate glucose metabolism in cancer cells through different ways, such as by directly regulating the glycolytic enzymes and glucose transporters (GLUTs), or indirectly modulating the signaling pathways. In this review, we summarized the role of lncRNAs in regulating glucose metabolism in cancer, which will help understand better the pathogenesis of malignant tumors. The understanding of the role of lncRNAs in glucose metabolism may help provide new therapeutic targets and novel diagnostic and prognosis markers for human cancer.

Keywords: Glucose metabolism; LncRNAs; Signaling pathway; Targeted therapy; Warburg effect.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Glucose / metabolism*
Glycolysis / physiology
Humans
Neoplasms / metabolism*
RNA, Long Noncoding / metabolism*
Signal Transduction / physiology

Substances

RNA, Long Noncoding
Glucose