Component-resolved diagnosis in hymenoptera allergy

Allergol Immunopathol (Madr). May-Jun 2018;46(3):253-262. doi: 10.1016/j.aller.2017.05.003. Epub 2017 Jul 22.


Component-resolved diagnosis based on the use of well-defined, properly characterised and purified natural and recombinant allergens constitutes a new approach in the diagnosis of venom allergy. Prospective readers may benefit from an up-to-date review on the allergens. The best characterised venom is that of Apis mellifera, whose main allergens are phospholipase A2 (Api m1), hyaluronidase (Api m2) and melittin (Api m4). Additionally, in recent years, new allergens of Vespula vulgaris have been identified and include phospholipase A1 (Ves v1), hyaluronidase (Ves v2) and antigen 5 (Ves v5). Polistes species are becoming an increasing cause of allergy in Europe, although only few allergens have been identified in this venom. In this review, we evaluate the current knowledge about molecular diagnosis in hymenoptera venom allergy.

Keywords: Allergy; Anaphylaxis; Apis; Component resolved diagnosis; Cross-reactivity; Hymenoptera; Insect stings; Polistes; Vespula.

Publication types

  • Review

MeSH terms

  • Allergens / analysis
  • Allergens / chemistry
  • Allergens / immunology*
  • Animals
  • Arthropod Venoms / chemistry
  • Arthropod Venoms / immunology*
  • Humans
  • Hymenoptera / chemistry
  • Hymenoptera / immunology*
  • Hypersensitivity / diagnosis*
  • Hypersensitivity / immunology
  • Insect Bites and Stings / immunology*


  • Allergens
  • Arthropod Venoms