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. 2017 Oct;214(4):701-706.
doi: 10.1016/j.amjsurg.2017.07.002. Epub 2017 Jul 8.

Idiopathic Granulomatous Mastitis: A Diagnostic and Therapeutic Challenge

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Idiopathic Granulomatous Mastitis: A Diagnostic and Therapeutic Challenge

C M Freeman et al. Am J Surg. .

Abstract

Background: Idiopathic granulomatous mastitis is a rare benign breast disease of women of reproductive age. It usually presents as a painful mass. Since the etiology is unclear, directed diagnosis and management is lacking.

Methods: This is a retrospective chart review of 14 patients, over twelve years (2004-2016), identified through query of pathology findings.

Results: Two asymptomatic patients were diagnosed after oncologic breast resection following neoadjuvant chemotherapy. The remaining twelve patients were young (31.7 years, range 23-43 years), predominantly non-white (50% African/African-American, 36% Hispanic, 7% Asian), pregnant within the last five years (86%), with no prior granulomatous disease. Evaluation included breast imaging, microbial cultures and staining, and biopsy. Treatment included antibiotics (57%), corticosteroids (21%), methotrexate (7%), and/or surgery (71%). Imaging suggests segmental masses, possibly abscess.

Conclusion: Granulomatous mastitis is uncommon, and difficult to diagnose and manage. We review our experience, the literature, and propose an algorithm for diagnosis and management.

Keywords: Breast; Diagnosis; Granulomatous mastitis; Management; Treatment.

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