Intramyocellular lipid droplets and insulin sensitivity, the human perspective

Anne Gemmink; Bret H Goodpaster; Patrick Schrauwen; Matthijs K C Hesselink

doi:10.1016/j.bbalip.2017.07.010

Intramyocellular lipid droplets and insulin sensitivity, the human perspective

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1242-1249. doi: 10.1016/j.bbalip.2017.07.010. Epub 2017 Jul 22.

Authors

Anne Gemmink¹, Bret H Goodpaster², Patrick Schrauwen¹, Matthijs K C Hesselink³

Affiliations

¹ Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200MD Maastricht, The Netherlands.
² Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA.
³ Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200MD Maastricht, The Netherlands. Electronic address: matthijs.hesselink@maastrichtuniversity.nl.

PMID: 28739280
DOI: 10.1016/j.bbalip.2017.07.010

Abstract

Skeletal muscle can store excess fat as subcellular lipid droplets (LDs). While originally viewed as uninteresting static balls of triacylglycerol, it is now clear that myocellular LDs play an active role in myocellular (patho)physiology. In this review we aim to discuss the role of LDs in muscle cell insulin sensitivity and identify parameters which appear to affect this relationship. Moreover, we discuss the application of novel tools permitting detailed examination of these parameters. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

Keywords: Human; IMCL; Insulin resistance; PLIN5; Skeletal muscle.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Insulin Resistance*
Lipid Droplets / metabolism*
Lipid Metabolism*
Muscle, Skeletal / metabolism*