The ESP Coordinating Center (ESP CC) is responding to a request from Office of Community Engagement’s (OCE) Center for Compassionate Innovation (CCI) for an evidence brief on the effectiveness of stellate ganglion block (SGB) for treatment of posttraumatic stress disorder (PTSD). Findings from this evidence brief will be used to inform Subject Matter Experts’ consideration of clinical use and research and program prioritization for SGB for PTSD in VA.