Monodisperse Dual Plasmonic Au@Cu 2-x E (E= S, Se) Core@Shell Supraparticles: Aqueous Fabrication, Multimodal Imaging, and Tumor Therapy at in Vivo Level

ACS Nano. 2017 Aug 22;11(8):8273-8281. doi: 10.1021/acsnano.7b03369. Epub 2017 Aug 1.

Abstract

We herein report aqueous fabrication of well-defined Au@Cu2-xE (E = S, Se) core@shell dual plasmonic supraparticles (SPs) for multimodal imaging and tumor therapy at the in vivo level. By means of a modified self-limiting self-assembly based strategy, monodisperse core@shell dual plasmonic SPs, including spherical Au@Cu2-xS SPs, Au@Cu2-xSe SPs, and rod-like Au@Cu2-xS SPs, are reliably and eco-friendly fabricated in aqueous solution. Due to plasmonic coupling from the core and shell materials, the as-prepared hybrid products possess an extremely large extinction coefficient (9.32 L g-1 cm-1 for spherical Au@Cu2-xS SPs) at 808 nm, which endows their excellent photothermal effect. Furthermore, the hybrid core@shell SPs possess the properties of good biocompatibility, low nonspecific interactions, and high photothermal stability. So, they show favorable performances for photoacoustic imaging and X-ray computed tomography imaging as well as photothermal therapy of tumors, indicating their application potentials in biological field.

Keywords: core@shell; dual plasmonic; multimodal imaging; self-assembly; supraparticles; tumor therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Contrast Media / chemistry*
  • Female
  • Gold / chemistry*
  • Metal Nanoparticles / chemistry*
  • Mice
  • Microscopy, Fluorescence
  • Multimodal Imaging / methods*
  • Phototherapy
  • Tomography, X-Ray Computed

Substances

  • Contrast Media
  • Gold