Progressive potential of mild cervical atypia: prospective cytological, colposcopic, and virological study

Lancet. 1986 Aug 2;2(8501):237-40. doi: 10.1016/s0140-6736(86)92067-2.


A prospective study of 100 women with cytological and colposcopic evidence of mild cervical atypia consistent with cervical intraepithelial neoplasia (CIN) grade I was started in October, 1983. 26% of early preinvasive cervical lesions progressed to histologically proven CIN III. Spontaneous regression of mild cervical atypia occurred in only 11 cases, and in 4 of these CIN recurred. The overall prevalence of human papillomavirus type 16 (HPV 16) in the study group, detected by filter DNA-DNA hybridisation of a cervical cytological specimen, was 39%. However, 22 of the 26 (85%) cases of progressive disease were positive for HPV 16. Detection of HPV 16 may be a non-invasive way of identifying women at high risk of rapid progression of mild cervical atypia to CIN III.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Carcinoma in Situ / pathology
  • Cervix Uteri / cytology
  • Colposcopy
  • DNA, Viral / analysis
  • Female
  • Humans
  • Nucleic Acid Hybridization
  • Papillomaviridae
  • Prospective Studies
  • Tumor Virus Infections / complications
  • Uterine Cervical Dysplasia / microbiology
  • Uterine Cervical Dysplasia / pathology*
  • Uterine Cervical Neoplasms / pathology


  • DNA, Viral