Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer

Dev Cell. 2017 Jul 24;42(2):112-114. doi: 10.1016/j.devcel.2017.07.004.

Abstract

The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is a major nutrient sensor and regulator of cellular metabolic flux. Reporting recently in Nature, Zabala-Letona et al. (2017) show that mTORC1 regulates an additional branch of metabolism in the cell-polyamine synthesis-that is important for prostate cancer tumorigenicity.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Multiprotein Complexes*
  • Neoplasms
  • Polyamines
  • Signal Transduction
  • TOR Serine-Threonine Kinases*

Substances

  • Multiprotein Complexes
  • Polyamines
  • TOR Serine-Threonine Kinases