Multidrug resistant bacteria are sensitive to Euphorbia prostrata and six others Cameroonian medicinal plants extracts

BMC Res Notes. 2017 Jul 25;10(1):321. doi: 10.1186/s13104-017-2665-y.

Abstract

Background: Multidrug resistant (MDR) bacteria are responsible for therapeutic failure and there is an urgent need for novels compounds efficient on them.

Methods: Eleven methanol extracts from seven Cameroonian medicinal plants were tested for their antibacterial activity using broth micro-dilution method against 36 MDR bacterial strains including Escherichia coli, Enterobacter aerogenes, Enterobacter cloacae, Klebsiella pneumoniae, Providencia stuartii, Pseudomonas aeruginosa and Staphylococcus aureus.

Results: Euphorbia prostrata extract was found active against all the 36 tested bacteria including Gram-negative phenotypes over-expressing efflux pumps such as P. aeruginosa PA124, E. aerogenes CM64 and E. coli AG102. E. prostrata had minimal inhibitory concentrations values between 128 and 256 µg/mL on 55.55% of the studied microorganisms. Other plants extract displayed selective antibacterial activity.

Conclusions: Results obtained in this study highlight the antibacterial potential of the tested plants and the possible use of E. prostrata to combat bacterial infections including MDR phenotypes.

Keywords: Antimicrobial; Cameroon; Euphorbia prostrata; Medicinal plant; Multidrug resistance.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects*
  • Cameroon
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Euphorbia / chemistry*
  • Microbial Sensitivity Tests
  • Phytochemicals / pharmacology
  • Plant Extracts / pharmacology*
  • Plants, Medicinal / chemistry*

Substances

  • Anti-Bacterial Agents
  • Phytochemicals
  • Plant Extracts