A double-blind study comparing an acellular pertussis-component DTP vaccine with a whole-cell pertussis-component DTP vaccine in 18-month-old children

Am J Dis Child. 1986 Sep;140(9):872-6. doi: 10.1001/archpedi.1986.02140230042025.


An acellular pertussis-component diphtheria-tetanus-pertussis (AC-DTP) vaccine was compared with a currently licensed, whole-cell pertussis-component DTP (WC-DTP) vaccine for reactogenicity and immunogenicity when given as the fourth DTP immunization in sixty 18- to 24-month-old children. Reactions over the first 48 hours were significantly less common in the AC-DTP vaccine recipients, as follows (WC-DTP/AC-DTP): fever, 85%/5%; redness, 70%/12.5%; tenderness, 100%/22.5%; swelling, 35%/10%; fretfulness, 70%/12.5%; anorexia, 35%/2.5%; and vomiting, 10%/0%. Antibody responses to pertussis antigens (agglutinogens, lymphocytosis-promoting factor, and filamentous hemagglutinin), diphtheria toxoid, and tetanus toxoid in AC-DTP vaccine recipients were comparable with those in WC-DTP vaccine recipients. The AC-DTP vaccine evaluated in this trial seems to be as immunogenic as WC-DTP vaccine while being markedly less reactogenic.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agglutinins / analysis
  • Antibodies, Bacterial / analysis
  • Antibody Formation
  • Bordetella pertussis / immunology
  • Clinical Trials as Topic
  • Diphtheria Toxoid / adverse effects
  • Diphtheria Toxoid / immunology*
  • Double-Blind Method
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immunization, Secondary
  • Infant
  • Pertussis Vaccine / adverse effects
  • Pertussis Vaccine / immunology*
  • Pertussis Vaccine / standards
  • Tetanus Toxoid / adverse effects
  • Tetanus Toxoid / immunology*
  • Vaccination


  • Agglutinins
  • Antibodies, Bacterial
  • Diphtheria Toxoid
  • Pertussis Vaccine
  • Tetanus Toxoid