The osteoarthritis and height GDF5 locus yields its secrets

Nat Genet. 2017 Jul 27;49(8):1165-1166. doi: 10.1038/ng.3924.


A new study reports molecular characterization of the GDF5 locus, which is associated with osteoarthritis risk and adult height in humans. This study provides evidence of positive selection for short stature at GDF5 in modern humans, as well as in archaic Neandertals and Denisovans.

MeSH terms

  • Growth Differentiation Factor 5*
  • Humans
  • Osteoarthritis*


  • Growth Differentiation Factor 5