STING Signaling in Cancer Cells: Important or Not?

Arch Immunol Ther Exp (Warsz). 2018 Apr;66(2):125-132. doi: 10.1007/s00005-017-0481-7. Epub 2017 Jul 26.


Stimulator of interferon genes (STING) is an adaptor protein that plays an important role in the activation of type I interferons in response to cytosolic nucleic acid ligands. Recent evidence indicates involvement of the STING pathway in the induction of antitumor immune response. Therefore, STING agonists are now being extensively developed as a new class of cancer therapeutics. However, little is known about the consequences of activated STING-mediated signaling in cancer cells on the efficacy of the antitumor treatment. It has been shown that activation of the STING-dependent pathway in cancer cells can result in tumor infiltration with immune cells and modulation of the anticancer immune response. Understanding the function of STING pathway in cancer cells might provide important insights into the development of effective therapeutic strategies. This review focuses on the role of STING pathway in cancer cells, the largely unknown topic that has recently emerged to be important in the context of STING-mediated antitumor responses.

Keywords: Cancer immunology; Cyclic dinucleotides; Innate immunity; STING; Type I interferons.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Cell Movement
  • Humans
  • Immunity, Innate
  • Immunotherapy / methods*
  • Interferon Type I / metabolism
  • Membrane Proteins / agonists
  • Membrane Proteins / metabolism*
  • Neoplasms / immunology*
  • Signal Transduction


  • Antineoplastic Agents
  • Interferon Type I
  • Membrane Proteins
  • STING1 protein, human