Accelerator-free Gloves as Alternatives in Cases of Glove Allergy in Healthcare Workers

Contact Dermatitis. 2018 Jan;78(1):28-32. doi: 10.1111/cod.12860. Epub 2017 Jul 27.


Background: Accelerators in rubber gloves constitute an important group of contact allergens, particularly in healthcare workers.

Objectives: To assess the efficacy of accelerator-free medical gloves in the secondary prevention of allergic contact dermatitis caused by rubber accelerators in healthcare workers.

Methods: Nine healthcare workers with hand eczema were advised to use accelerator-free rubber gloves after a diagnosis of allergic contact dermatitis caused by rubber accelerators.

Results: Switching from conventional medical single-use gloves containing accelerators to accelerator-free medical gloves led to improvement in all cases, and more than two-thirds of the patients were completely free of symptoms.

Conclusion: The use of accelerator-free medical gloves can be an effective alternative in healthcare workers who are allergic to rubber accelerators.

Keywords: accelerator-free gloves; allergic contact dermatitis; glove allergy; healthcare workers; prevention; rubber accelerators; thiurams.

MeSH terms

  • Adult
  • Allergens / adverse effects
  • Dermatitis, Allergic Contact / etiology
  • Dermatitis, Allergic Contact / prevention & control*
  • Dermatitis, Occupational / etiology
  • Dermatitis, Occupational / prevention & control*
  • Female
  • Gloves, Surgical / adverse effects*
  • Hand Dermatoses / chemically induced
  • Hand Dermatoses / prevention & control*
  • Health Care Sector*
  • Humans
  • Latex Hypersensitivity / chemically induced
  • Male
  • Middle Aged
  • Rubber / chemical synthesis
  • Rubber / chemistry
  • Secondary Prevention / methods
  • Thiocarbamates / adverse effects
  • Thiram / adverse effects
  • Thiram / analogs & derivatives


  • Allergens
  • Thiocarbamates
  • Thiram
  • Rubber