Emerging diagnostic challenges and characteristics of simian betaretrovirus infections in captive macaque colonies

J Med Primatol. 2017 Aug;46(4):149-153. doi: 10.1111/jmp.12295.


To better understand Simian betaretrovirus (SRV) seropositivity in virus-negative macaques, we transfused blood from SRV-infected or suspect donors into immunosuppressed naive recipients. Our results do not support typical SRV1-5 infection as the cause, but provide evidence for several possibilities including serological artifact, new/different SRV, or an endogenous virus.

Keywords: PCR; endogenous virus; serology; transfusion.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Betaretrovirus / physiology*
  • Macaca*
  • Monkey Diseases / diagnosis*
  • Monkey Diseases / virology
  • Retroviridae Infections / diagnosis*
  • Retroviridae Infections / virology