B and T lymphocytes regulated by idiotype anti-idiotype interactions inhibit delayed-type hypersensitivity to BCG in mice

Cell Immunol. 1986 Mar;98(1):93-103. doi: 10.1016/0008-8749(86)90270-4.


Mice infected subcutaneously with 2 X 10(7) CFU of Mycobacterium bovis strain BCG (BCG) were able to mount a specific DTH response, whereas mice infected intravenously with the same dose of microorganisms were not. The suppression turned out to be mediated by id+ anti-PPD B lymphocytes, which arose very early during the infectious process and induced anti-id B lymphocytes. These cells were found at Day 4 after infection and exerted their effect by activating antigen-specific suppressor T lymphocytes, which affected the efferent phase of the DTH response. These results clearly indicate that the activation of a complex immunosuppressive circuit represents a mechanism by which BCG may interfere with the host's immune response already during the very early phases of infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Anti-Idiotypic / physiology
  • B-Lymphocytes / classification
  • B-Lymphocytes / immunology*
  • BCG Vaccine / administration & dosage
  • BCG Vaccine / immunology*
  • Hypersensitivity, Delayed / immunology*
  • Immunity, Cellular
  • Immunoglobulin Idiotypes / immunology*
  • Injections, Intravenous
  • Injections, Subcutaneous
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • T-Lymphocytes / classification
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Regulatory / immunology


  • Antibodies, Anti-Idiotypic
  • BCG Vaccine
  • Immunoglobulin Idiotypes