Effect of alprazolam and diazepam on anxiety and panic attacks in panic disorder: a controlled study

J Clin Psychiatry. 1986 Sep;47(9):458-60.


Forty-eight patients currently experiencing panic attacks were randomly assigned to double-blind treatment with alprazolam, diazepam, or placebo. Efficacy was assessed using the Hamilton Rating Scale for Anxiety and a panic attack frequency rating scale. Results indicate that the two active treatments appeared equally effective in reducing both the frequency of panic attacks and the severity of generalized anxiety when compared with placebo. Overall, these data support the use of benzodiazepines in the treatment of panic disorder.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Alprazolam
  • Anti-Anxiety Agents / therapeutic use*
  • Anxiety Disorders / drug therapy*
  • Anxiety Disorders / psychology
  • Benzodiazepines / therapeutic use*
  • Clinical Trials as Topic
  • Diazepam / therapeutic use*
  • Double-Blind Method
  • Fear* / drug effects
  • Female
  • Humans
  • Male
  • Panic* / drug effects
  • Placebos
  • Psychiatric Status Rating Scales


  • Anti-Anxiety Agents
  • Placebos
  • Benzodiazepines
  • Diazepam
  • Alprazolam