The anti-aging and anti-oxidation effects of tea water extract in Caenorhabditis elegans

Exp Gerontol. 2017 Oct 15;97:89-96. doi: 10.1016/j.exger.2017.07.015. Epub 2017 Jul 25.


Tea includes puer tea, black tea, green tea and many others. By using model organism Caenorhabditis elegans, the anti-aging and anti-oxidation effects of tea water extract were systemically examined in this study. We found that water extract of puer tea, black tea and green tea all increased the lifespan of worms, postponed Aβ-induced progressive paralysis in Alzheimer's disease transgenic worms, and improved the tolerance of worms to the oxidative stress induced by heavy metal Cr6+. Moreover, the anti-oxidation effects of tea water extract at low concentration were different among 4 kinds of brands of green tea. The underlying mechanisms were further explored using genetically manipulated-mutant worms. The anti-oxidative stress effects of green tea water extract depend on the dietary restriction and germline signaling pathways, but not the FOXO and mitochondrial respiratory chain signals. Therefore, tea water extract provides benefits of anti-aging, anti-AD and anti-oxidation.

Keywords: Aging; Alzheimer's disease; Oxidative stress; Tea water extract.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Antioxidants / pharmacology*
  • Caenorhabditis elegans / drug effects*
  • Caenorhabditis elegans / physiology
  • Forkhead Transcription Factors / metabolism
  • Oxidation-Reduction
  • Oxidative Stress / drug effects*
  • Plant Extracts / pharmacology*
  • Signal Transduction / drug effects
  • Tea / chemistry*


  • Antioxidants
  • Forkhead Transcription Factors
  • Plant Extracts
  • Tea