Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses

Andre A Teixeira; Serena Marchiò; Emmanuel Dias-Neto; Diana N Nunes; Israel T da Silva; Bryce Chackerian; Marc Barry; Richard C Lauer; Ricardo J Giordano; Richard L Sidman; Cosette M Wheeler; Webster K Cavenee; Renata Pasqualini; Wadih Arap

doi:10.15252/emmm.201708072

Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses

EMBO Mol Med. 2017 Oct;9(10):1327-1330. doi: 10.15252/emmm.201708072.

Authors

Andre A Teixeira^{1

2

3}, Serena Marchiò^{1

2

4

5}, Emmanuel Dias-Neto^{6

7}, Diana N Nunes⁶, Israel T da Silva⁸, Bryce Chackerian⁹, Marc Barry^{1

10}, Richard C Lauer^{1

11}, Ricardo J Giordano³, Richard L Sidman¹², Cosette M Wheeler^{1

11}, Webster K Cavenee¹³, Renata Pasqualini^{1

2}, Wadih Arap^{1

11}

Affiliations

¹ University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
² Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
³ Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil.
⁴ Department of Oncology, University of Torino School of Medicine, Torino, TO, Italy.
⁵ Candiolo Cancer Institute-Fondazione del Piemonte per l'Oncologia (FPO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, TO, Italy.
⁶ Laboratory of Medical Genomics, A.C.Camargo Cancer Center, São Paulo, Brazil.
⁷ Laboratory of Neurosciences, Institute of Psychiatry, University of São Paulo, São Paulo, Brazil.
⁸ Laboratory of Computational Biology, A.C.Camargo Cancer Center, São Paulo, Brazil.
⁹ Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM, USA.
¹⁰ Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
¹¹ Division of Hematology/Oncology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
¹² Department of Neurology, Harvard Medical School, Boston, MA, USA.
¹³ Ludwig Institute for Cancer Research, University of California-San Diego, La Jolla, CA, USA.

Abstract

The hypothesis is discussed that prostate cancer marker lncRNA PCA3 was introduced into the human genome by an oncogenic virus, and that viral infection‐related mechanisms might underlie its overexpression and prostate cancer initiation and/or progression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Neoplasm / genetics*
Base Sequence
Biomarkers, Tumor / genetics*
Computer Simulation
Humans
Male
Neoplasm Proteins / metabolism
Oncogenic Viruses / genetics*
Prostatic Neoplasms / genetics*
Prostatic Neoplasms / virology*
RNA, Long Noncoding / genetics*
Tumor Virus Infections / genetics

Substances

Antigens, Neoplasm
Biomarkers, Tumor
Neoplasm Proteins
PRUNE2 protein, human
RNA, Long Noncoding
prostate cancer antigen 3, human

Grants and funding

P30 CA118100/CA/NCI NIH HHS/United States