The Role of Th17 Cells in the Pathogenesis of Behcet's Disease

J Clin Med. 2017 Jul 21;6(7):74. doi: 10.3390/jcm6070074.


Behcet's disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic course and unknown cause. The pathogenesis of BD has not been fully elucidated; however, BD has been considered to be a typical Th1-mediated inflammatory disease, characterized by elevated levels of Th1 cytokines such as IFN-γ, IL-2, and TNF-α. Recently, some studies reported that Th17-associated cytokines were increased in BD; thus, Th17 cells and the IL17/IL23 pathway may play important roles in the pathogenesis of BD. In this chapter, we focus on the pathogenic role of Th17 cells in BD.

Keywords: Behcet’s disease; IL-17; Th1; Th17; regulatory T cells.

Publication types

  • Review