A regularized variable selection procedure in additive hazards model with stratified case-cohort design

Lifetime Data Anal. 2018 Jul;24(3):443-463. doi: 10.1007/s10985-017-9402-7. Epub 2017 Jul 28.


Case-cohort designs are commonly used in large epidemiological studies to reduce the cost associated with covariate measurement. In many such studies the number of covariates is very large. An efficient variable selection method is needed for case-cohort studies where the covariates are only observed in a subset of the sample. Current literature on this topic has been focused on the proportional hazards model. However, in many studies the additive hazards model is preferred over the proportional hazards model either because the proportional hazards assumption is violated or the additive hazards model provides more relevent information to the research question. Motivated by one such study, the Atherosclerosis Risk in Communities (ARIC) study, we investigate the properties of a regularized variable selection procedure in stratified case-cohort design under an additive hazards model with a diverging number of parameters. We establish the consistency and asymptotic normality of the penalized estimator and prove its oracle property. Simulation studies are conducted to assess the finite sample performance of the proposed method with a modified cross-validation tuning parameter selection methods. We apply the variable selection procedure to the ARIC study to demonstrate its practical use.

Keywords: Additive hazards model; Diverging number of parameters; SCAD; Stratified case-cohort design; Survival analysis; Variable selection.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Atherosclerosis
  • Biostatistics / methods*
  • Cohort Studies
  • Epidemiologic Studies
  • Humans
  • Proportional Hazards Models*
  • Risk Assessment / statistics & numerical data
  • Survival Analysis*