Effect of silver nanoparticles upon the myocardial and coronary vascular function in isolated and perfused diabetic rat hearts

Nanomedicine. 2017 Nov;13(8):2587-2596. doi: 10.1016/j.nano.2017.07.007. Epub 2017 Jul 26.


Silver nanoparticles (AgNPs) are promising antibacterial nanomaterials for diagnostic and treatment of diabetes. However, toxicity and adverse cardiac responses induced by AgNPs related to nitric oxide (NO) and oxidative stress (OS) are described. Moreover, little is known about the diabetes influence upon AgNPs-toxicity. The aim of this work was to evaluate cardiovascular function in response to AgNPs through measuring perfusion pressure (PP) and left ventricle pressure (LVP), using perfused hearts from streptozotocin (STZ)-induced diabetic rats and identify the role of NO and OS. High concentrations but not the lower concentrations of AgNPs, promotes increases in PP and LVP, as well as increased OS. Additionally, diabetes alters the classic effects of phenylephrine (Phe) and acetylcholine (ACh). These data suggest that diabetes may intensify AgNPs-cardiotoxicity. Nevertheless, the precise mechanism of action is still under elucidation.

Keywords: Diabetic rats; Nitric oxide; Oxidative stress; Silver nanoparticles.

MeSH terms

  • Acetylcholine / metabolism
  • Animals
  • Diabetes Mellitus, Experimental / metabolism
  • Diabetes Mellitus, Experimental / physiopathology*
  • Heart / drug effects*
  • Heart / physiopathology*
  • Male
  • Metal Nanoparticles / toxicity*
  • Myocardium / metabolism
  • Nitric Oxide / metabolism
  • Oxidative Stress / drug effects*
  • Rats, Wistar
  • Silver / toxicity*


  • Nitric Oxide
  • Silver
  • Acetylcholine