Infection-mediated autoimmune movement disorders

Parkinsonism Relat Disord. 2018 Jan;46 Suppl 1:S83-S86. doi: 10.1016/j.parkreldis.2017.07.019. Epub 2017 Jul 21.


Infectious diseases remain the most common cause of neurological disability in the world. A number of movement disorders can develop in adults and children in response to infections. These can occur in isolation or as part of a broader neurological illness, with movement abnormalities consequent to an encephalopathy or a broader brain dysfunction. While most infection-related movement disorders are direct consequences of an active infectious process affecting cerebral structures implied in the motor network, at times a delayed immune-mediated process in response to a previous infectious is responsible for the neurological dysfunction. This immunological response can occur as a consequence of a number of pathogens, and develop at variable times after the initial infection. The most common infection-mediated autoimmune movement disorders are chorea, which is especially common in children, and other hyperkinetic disorders, but Parkinsonism and other hypokinetic movement disorders may also occur.

Keywords: Autoimmune; Infection; Movement disorders.

Publication types

  • Review

MeSH terms

  • Autoimmune Diseases / complications
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / etiology*
  • Communicable Diseases / complications*
  • Humans
  • Movement Disorders / complications
  • Movement Disorders / diagnosis
  • Movement Disorders / etiology*