Thyrotropin binding inhibitor immunoglobulin. Its pathogenetic importance in hypothyroidism

Am J Dis Child. 1986 Oct;140(10):998-1000. doi: 10.1001/archpedi.1986.02140240044023.


Two patients with hypothyroidism had detectable serum levels of thyrotropin binding inhibitor immunoglobulin (TBII). Patient 1 was a newborn infant who had transient neonatal hypothyroidism due to transfer of TBII from the mother with nongoitrous autoimmune thyroiditis. Patient 2 was an 8-year-old girl with Down's syndrome who presented with signs of myxedema and central precocious puberty. She had no goiter, and the recognition of thyroid disease was delayed; the histological diagnosis of chronic lymphocytic thyroiditis was established by aspiration biopsy, and TBII had strong thyroid adenyl cyclase-inhibiting activity in vitro. It appears that TBII may be pathogenetically important for occurrence of neonatal hypothyroidism and nongoitrous autoimmune thyroiditis without goiter.

Publication types

  • Case Reports

MeSH terms

  • Adenylyl Cyclases / analysis
  • Adult
  • Autoimmune Diseases / immunology
  • Child
  • Female
  • Humans
  • Hypothyroidism / enzymology
  • Hypothyroidism / etiology
  • Hypothyroidism / immunology*
  • Immunoglobulin G / analysis*
  • Immunoglobulins, Thyroid-Stimulating
  • Infant, Newborn
  • Maternal-Fetal Exchange
  • Pregnancy
  • Pregnancy Complications / immunology
  • Thyroiditis, Autoimmune / immunology


  • Immunoglobulin G
  • Immunoglobulins, Thyroid-Stimulating
  • Adenylyl Cyclases