Concomitant Epstein-Barr Virus-associated smooth muscle tumor and granulomatous inflammation of the liver

Pathol Res Pract. 2017 Oct;213(10):1306-1309. doi: 10.1016/j.prp.2017.07.008. Epub 2017 Jul 13.

Abstract

Epstein-Barr Virus-associated smooth muscle tumor (EBV-SMT) is a rare mesenchymal tumor typically seen in immunocompromised patients. Here, we report a case of EBV-SMT and associated granulomatous inflammation in the liver of a 32-year-old man with history of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). To our knowledge, an association of these two lesions has not been previously reported. We review the literature and discuss pathogenesis, differential diagnosis and immunohistochemical (IHC) stains helpful for the diagnosis of this rare entity. Finally, we consider possible explanations for the concomitant presence of these lesions.

Keywords: Epstein-Bar Virus-associated smooth muscle tumor; granulomatous inflammation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / diagnosis
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / virology
  • Adult
  • Biopsy, Large-Core Needle
  • Diagnosis, Differential
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration
  • Epstein-Barr Virus Infections / diagnosis
  • Epstein-Barr Virus Infections / immunology
  • Epstein-Barr Virus Infections / virology*
  • Granuloma / diagnosis
  • Granuloma / immunology
  • Granuloma / virology*
  • Hepatitis / diagnosis
  • Hepatitis / immunology
  • Hepatitis / virology*
  • Humans
  • Immunocompromised Host
  • Immunohistochemistry
  • Male
  • Predictive Value of Tests
  • Smooth Muscle Tumor / diagnosis
  • Smooth Muscle Tumor / immunology
  • Smooth Muscle Tumor / virology*