Immune correlates of protection for dengue: State of the art and research agenda

Vaccine. 2017 Aug 24;35(36):4659-4669. doi: 10.1016/j.vaccine.2017.07.045. Epub 2017 Jul 28.


Dengue viruses (DENV1-4) are mosquito-borne flaviviruses estimated to cause up to ∼400 million infections and ∼100 million dengue cases each year. Factors that contribute to protection from and risk of dengue and severe dengue disease have been studied extensively but are still not fully understood. Results from Phase 3 vaccine efficacy trials have recently become available for one vaccine candidate, now licensed for use in several countries, and more Phase 2 and 3 studies of additional vaccine candidates are ongoing, making these issues all the more urgent and timely. At the "Summit on Dengue Immune Correlates of Protection", held in Annecy, France, on March 8-9, 2016, dengue experts from diverse fields came together to discuss the current understanding of the immune response to and protection from DENV infection and disease, identify key unanswered questions, discuss data on immune correlates and plans for comparison of results across assays/consortia, and propose a research agenda for investigation of dengue immune correlates, all in the context of both natural infection studies and vaccine trials.

Keywords: Dengue virus; Immune correlates of protection; Immune correlates of risk; Natural infection; Vaccine.

MeSH terms

  • Antibodies, Neutralizing / biosynthesis
  • Antibodies, Neutralizing / immunology
  • Antibodies, Viral / immunology*
  • Clinical Trials, Phase II as Topic
  • Clinical Trials, Phase III as Topic
  • Congresses as Topic
  • Dengue / immunology*
  • Dengue / prevention & control
  • Dengue Vaccines
  • Dengue Virus / genetics
  • Dengue Virus / immunology*
  • Humans
  • Severe Dengue / immunology*
  • Severe Dengue / prevention & control


  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Dengue Vaccines