Cumulative renal tubular damage associated with cisplatin nephrotoxicity

Cancer Chemother Pharmacol. 1986;18(1):69-73. doi: 10.1007/BF00253068.


We assessed the acute and chronic effect of multiple courses of cisplatin therapy on renal tubules by monitoring the urinary excretion of alanine aminopeptidase, N-acetyl-beta-D-glucosaminidase, and total protein. Urine specimens were obtained before and after doses of cisplatin (90 mg/m2) given to 12 patients. Each dose of cisplatin induced transient increases in enzyme excretion, followed by proteinuria 3-5 days later. Transient enzymuria after the last cisplatin dose was significantly greater than that after the first dose. Moreover, persistent increases in urinary N-acetyl-beta-D-glucosaminidase and serum creatinine concentrations over pretherapy levels indicated chronic renal tubular damage. Our findings disclosed striking differences between patients in susceptibility to progressive nephrotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylglucosaminidase / urine
  • Adolescent
  • Aminopeptidases / urine
  • CD13 Antigens
  • Child
  • Child, Preschool
  • Cisplatin / adverse effects*
  • Creatinine / blood
  • Female
  • Humans
  • Kidney Tubules / drug effects*
  • Male
  • Proteinuria / chemically induced


  • Creatinine
  • Acetylglucosaminidase
  • Aminopeptidases
  • CD13 Antigens
  • Cisplatin