Biological, medicinal and toxicological significance of Eucalyptus leaf essential oil: a review

J Sci Food Agric. 2018 Feb;98(3):833-848. doi: 10.1002/jsfa.8600. Epub 2017 Sep 11.


The genus Eucalyptus L'Heritier comprises about 900 species, of which more than 300 species contain volatile essential oil in their leaves. About 20 species, within these, have a high content of 1,8-cineole (more than 70%), commercially used for the production of essential oils in the pharmaceutical and cosmetic industries. However, Eucalyptus is extensively planted for pulp, plywood and solid wood production, but its leaf aromatic oil has astounding widespread biological activities, including antimicrobial, antiseptic, antioxidant, chemotherapeutic, respiratory and gastrointestinal disorder treatment, wound healing, and insecticidal/insect repellent, herbicidal, acaricidal, nematicidal, and perfumes, soap making and grease remover. In the present review, we have made an attempt to congregate the biological ingredients of leaf essential oil, leaf oil as a natural medicine, and pharmacological and toxicological values of the leaf oil of different Eucalyptus species worldwide. © 2017 Society of Chemical Industry.

Keywords: Eucalyptus; biological properties; leaf essential oil; medicinal values; phytotoxicity; repellent activities.

Publication types

  • Review

MeSH terms

  • Animals
  • Eucalyptus / chemistry*
  • Humans
  • Oils, Volatile / pharmacology*
  • Oils, Volatile / toxicity
  • Plant Extracts / pharmacology*
  • Plant Extracts / toxicity
  • Plant Leaves / chemistry


  • Oils, Volatile
  • Plant Extracts