The salivary gland salivation stimulating peptide from Locusta migratoria (Lom-SG-SASP) is not a typical neuropeptide

PeerJ. 2017 Jul 26;5:e3619. doi: 10.7717/peerj.3619. eCollection 2017.


The salivary gland salivation stimulating peptide was identified from the salivary glands of the migratory locust by its ability to stimulate cAMP production in the same tissue. The gene coding for this peptide has recently been identified and been shown to code for a precursor consisting of a signal peptide, several copies of the peptide separated by Lys-Arg doublets and a few other peptides. These data are consistent with it being a neuropeptide. However, antiserum raised to this peptide labels the acini of the salivary glands while RT-PCR only gives positive results in the salivary gland, but not in any ganglion of the central nervous system. Thus, this peptide is not a typical neuropeptide as previously assumed.

Keywords: Antiserum; Immunohistology; PC1; PC2; RT-PCR; SG-SASP.

Grant support

This work was supported by institutional funding from the CNRS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.