Nomenclature and Serology of HLA Class I and Class II Alleles

Curr Protoc Immunol. 2017 Aug 1:118:A.1S.1-A.1S.6. doi: 10.1002/cpim.32.

Abstract

This overview presents nomenclature and serology information on human leucocyte antigens, or HLA molecules, which are encoded by a cluster of genes linked on the short arm of chromosome 6. This region is known as the major histocompatibility complex and codes for class I and class II molecules, which are distinguished from each other based upon their structure, tissue distribution, and source of peptide antigen, as well as upon their interactions with T cell subsets. © 2017 by John Wiley & Sons, Inc.

Keywords: HLA; HLA class I; HLA class II; MHC; human leucocyte antigens; major histocompatibility complex.

Publication types

  • Review

MeSH terms

  • Alleles
  • HLA Antigens* / blood
  • HLA Antigens* / classification
  • HLA Antigens* / genetics
  • Histocompatibility Antigens Class I* / blood
  • Histocompatibility Antigens Class I* / classification
  • Histocompatibility Antigens Class I* / genetics
  • Histocompatibility Antigens Class II* / blood
  • Histocompatibility Antigens Class II* / classification
  • Histocompatibility Antigens Class II* / genetics
  • Humans
  • Terminology as Topic

Substances

  • HLA Antigens
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II