Gastro-Esophageal Reflux in Children

Int J Mol Sci. 2017 Aug 1;18(8):1671. doi: 10.3390/ijms18081671.


Gastro-esophageal reflux (GER) is common in infants and children and has a varied clinical presentation: from infants with innocent regurgitation to infants and children with severe esophageal and extra-esophageal complications that define pathological gastro-esophageal reflux disease (GERD). Although the pathophysiology is similar to that of adults, symptoms of GERD in infants and children are often distinct from classic ones such as heartburn. The passage of gastric contents into the esophagus is a normal phenomenon occurring many times a day both in adults and children, but, in infants, several factors contribute to exacerbate this phenomenon, including a liquid milk-based diet, recumbent position and both structural and functional immaturity of the gastro-esophageal junction. This article focuses on the presentation, diagnosis and treatment of GERD that occurs in infants and children, based on available and current guidelines.

Keywords: children; extraintestinal symptoms; gastro-esophageal reflux; guidelines; infants.

Publication types

  • Review

MeSH terms

  • Child
  • Disease Progression
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / pathology*
  • Gastroesophageal Reflux / therapy
  • Humans
  • Practice Guidelines as Topic