Artificial food additive intolerance in patients with angio-oedema and urticaria

Lancet. 1986 Oct 18;2(8512):907-9. doi: 10.1016/s0140-6736(86)90423-x.


43 children who presented with angio-oedema and/or urticaria and who responded to an additive-free diet were challenged with artificial food additives in a double-blind study. 24 children reacted to 1 or more of the additives. 18 children did not react to any additives and remained well when a normal diet was re-introduced. Aspirin sensitivity was found in only 1 of the 24 children who could not tolerate additives. Atopy was less common in these patients than in the general population. The mechanism of additive intolerance is unknown and double-blind challenge is the only reliable means of diagnosis.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Angioedema / chemically induced*
  • Azo Compounds / adverse effects
  • Benzoates / adverse effects
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Diet
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Food Additives / adverse effects*
  • Food Hypersensitivity / etiology*
  • Humans
  • Male
  • Skin Tests
  • Urticaria / chemically induced*


  • Azo Compounds
  • Benzoates
  • Food Additives