Objective: To analysis the change of brain functional activity in the left and right peripheral facial paralysis by using resting-state functional magnetic resonance imaging (R-fMRI) of fraction amplitude of low frequency fluctuation(fALFF) measurement technique, and research the abnormal brain region with different side patients whether there are differences. Methods: A total of 43 patients with peripheral facial paralysis patients (patient groups, divided into left / right two subgroups) and 21 healthy volunteers (control group) in this study.Resting-state fMRI were acquired for each volunteer and patient. The fALFF approach was used to compare the peripheral facial paralysis groups to healthy group.Functional analysis was performed with brain function analysis software REST and DPARSFA , and then analysis the difference of two groups of patients and control group in two sample t test.At the same time, the correlation analysis between fALFF parameters map of the left and right side of two groups of patients and corresponding facial nerve grading TFGS score.Ultimately obtain a statistically significant brain regions. Results: Compared to healthy group, the decreased fALFF areas in the left side facial paralysis were showed in the right superior temporal gyrus , the pole of the right temporal, right middle temporal gyrus, the left occipital gyrus, and left medial cingulate gyrus, left paracentral lobule, and the left supplementary motor area; while the increased brain regions have the right superior frontal gyrus, right middle frontal gyrus, the right precentral gyrus, bilateral inferior temporal gyrus and middle temporal gyrus.Compared to healthy group, the decreased fALFF areas in the right side facial paralysis were showed in the right inferior temporal gyrus and fusiform gyrus, the left inferior occipital gyrus, the left superior parietalgyrus, the left inferior parietalgyrus, left precuneus, left paracentral lobule, the left supplementary motor area; while the increased brain regions have the left Calcarine, right lingual gyrus, corpus callosum, right medial cingulum gyrus.In the left facial paralysis group TFGS score was positively correlated with brain regions have left middle frontal gyrus, left precuneus and left cuneus, while the negatively related brain area on the right lingual gyrus.In the right facial paralysis groups TFGS score was positively correlated with brain areas have right inferior temporal gyrus and middle temporal gyrus, left inferior parietalgyrus; while the negatively correlated brain area on the left superior temporal gyrus, the right medial frontal gyrus. Conclusion: The left and right side facial paralysis patient's mood and motor function integration mechanism may be different, and the patient's emotional and psychological changes may be associated with disease severity.
目的： 使用静息态功能磁共振成像(R－fMRI)比率低频振幅(fALFF)测量技术探讨左、右周围性面神经麻痹患者的静息态脑功能活动是否存在异常，以及不同病侧患者异常脑区是否存在差异，以探讨周围性面神经麻痹患者可能的中枢整合机制。 方法： 对来自2015年1—12月北京伊济源面神经研究院的43例周围性面神经麻痹患者(患者组，分为左/右两组)及来自社会招募21名健康志愿者(对照组)进行静息态fMRI扫描，利用静息态脑功能后处理软件REST、DPARSFA将两组患者分别和对照组fALFF参数图进行双样本t检验，并同时将得到的两组患者的fALFF参数图与两组的面神经多伦多分级(TFGS)进行相关性分析，最终获取有统计意义的差异脑区。 结果： 左侧组相对于对照组fALFF值升高的脑区有右侧额上回、右侧额中回、右侧中央前回、双侧颞下回及颞中回，fALFF值降低的脑区有右侧颞上回及颞极、右侧颞中回，左侧枕下回、左侧内侧和旁扣带回，左侧中央旁小叶，左侧补充运动区。右侧组相对于对照组fALFF值升高的脑区有左侧距状裂周围皮质、右侧舌回、胼胝体，右侧内侧和旁扣带脑回，fALFF值降低的脑区有右侧颞下回及梭状回、左侧枕下回、左侧顶上回，左侧顶下回，左侧楔前叶、左侧中央旁小叶，左侧补充运动区。与左侧组的TFGS评分呈正相关的脑区有左侧额中回、左侧楔前叶、左侧楔叶，呈负相关的脑区有右侧舌回；与右侧组的TFGS评分呈正相关的脑区有右侧颞下回及颞中回、左侧顶下回，呈负相关的脑区有右侧内侧额上回。 结论： 静息态功能磁共振成像比率低频振幅测量技术在探测周围性面神经麻痹患者脑功能活动具有意义，左右侧面神经麻痹患者的情绪及运动功能整合机制可能存在不同，且患者的情绪及心理变化可能与疾病的严重程度密切相关。.
Keywords: Facial paralysis; Magnetic resonance imaging; fALFF.