The development of a novel knowledge-based weaning algorithm using pulmonary parameters: a simulation study

Med Biol Eng Comput. 2018 Mar;56(3):373-384. doi: 10.1007/s11517-017-1698-7. Epub 2017 Aug 2.


Weaning is important for patients and clinicians who have to determine correct weaning time so that patients do not become addicted to the ventilator. There are already some predictors developed, such as the rapid shallow breathing index (RSBI), the pressure time index (PTI), and Jabour weaning index. Many important dimensions of weaning are sometimes ignored by these predictors. This is an attempt to develop a knowledge-based weaning process via fuzzy logic that eliminates the disadvantages of the present predictors. Sixteen vital parameters listed in published literature have been used to determine the weaning decisions in the developed system. Since there are considered to be too many individual parameters in it, related parameters were grouped together to determine acid-base balance, adequate oxygenation, adequate pulmonary function, hemodynamic stability, and the psychological status of the patients. To test the performance of the developed algorithm, 20 clinical scenarios were generated using Monte Carlo simulations and the Gaussian distribution method. The developed knowledge-based algorithm and RSBI predictor were applied to the generated scenarios. Finally, a clinician evaluated each clinical scenario independently. The Student's t test was used to show the statistical differences between the developed weaning algorithm, RSBI, and the clinician's evaluation. According to the results obtained, there were no statistical differences between the proposed methods and the clinician evaluations.

Keywords: Fuzzy logic; Gaussian distribution method; Monte Carlo algorithm; RSBI; Weaning.

MeSH terms

  • Algorithms*
  • Blood Gas Analysis
  • Blood Pressure
  • Body Temperature
  • Carbon Dioxide / metabolism
  • Computer Simulation*
  • Fuzzy Logic
  • Glasgow Coma Scale
  • Hemodynamics
  • Hemoglobins / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Knowledge*
  • Lung / physiology*
  • Oxygen / metabolism
  • Respiratory Function Tests
  • Ventilator Weaning*


  • Hemoglobins
  • Carbon Dioxide
  • Oxygen