Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease

Cell Metab. 2017 Aug 1;26(2):281-283. doi: 10.1016/j.cmet.2017.07.006.


Plasma mannose levels are elevated in subjects with insulin resistance independently of obesity. Here, we found that elevated plasma mannose levels are strong markers of future risk of several chronic diseases including T2D, CVD, and albuminuria, and that it may contribute to their development rather than just being a novel biomarker.

Keywords: CVD; T2D; albuminuria; insulin resistance; mannose; metabolomics.

Publication types

  • Letter
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Albuminuria / blood*
  • Biomarkers / blood
  • Cardiovascular Diseases / blood*
  • Diabetes Mellitus, Type 2 / blood*
  • Female
  • Humans
  • Insulin Resistance*
  • Male
  • Mannose / blood*
  • Middle Aged


  • Biomarkers
  • Mannose