Epinephrine-induced memory facilitation: attenuation by adrenoceptor antagonists

Eur J Pharmacol. 1986 Sep 23;129(1-2):189-93. doi: 10.1016/0014-2999(86)90353-5.


The present study examined the relative importance of alpha- and beta-adrenoceptors in the memory modulatory effects of epinephrine. Posttraining epinephrine administration enhanced retention performance of a one-trial inhibitory avoidance response. Further pretraining injections of a variety of adrenoceptor antagonists, including selective alpha 1-, alpha 2-, beta 1- and/or beta 2-adrenoceptor antagonists, attenuated the retention enhancing effects of posttraining epinephrine. These results suggest that alpha- and beta-adrenoceptors of both subtypes are involved in the memory-modulating effects of epinephrine.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenergic alpha-Antagonists / pharmacology*
  • Adrenergic beta-Antagonists / pharmacology*
  • Animals
  • Avoidance Learning / drug effects
  • Epinephrine / antagonists & inhibitors
  • Epinephrine / pharmacology*
  • Male
  • Memory / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Receptors, Adrenergic, alpha / physiology
  • Receptors, Adrenergic, beta / physiology
  • Retention, Psychology / drug effects


  • Adrenergic alpha-Antagonists
  • Adrenergic beta-Antagonists
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic, beta
  • Epinephrine