Association of lymphocyte-monocyte ratio and monocyte-to-high-density lipoprotein ratio with the presence and severity of rheumatic mitral valve stenosis

Vahit Demir; Yilmaz Samet; Mehmet Kadri Akboga

doi:10.2217/bmm-2017-0036

Association of lymphocyte-monocyte ratio and monocyte-to-high-density lipoprotein ratio with the presence and severity of rheumatic mitral valve stenosis

Biomark Med. 2017 Aug;11(8):657-663. doi: 10.2217/bmm-2017-0036. Epub 2017 Aug 3.

Authors

Vahit Demir¹, Yilmaz Samet², Mehmet Kadri Akboga³

Affiliations

¹ Cardiology Clinic, Bozok University Hospital, 66200, Yozgat, Turkey.
² Cardiology Clinic, Pamukkale University Hospital, 20070, Denizli, Turkey.
³ Cardiology Clinic, Turkey Yuksek Ihtisas Education & Research Hospital, 06100, Ankara, Turkey.

PMID: 28770612
DOI: 10.2217/bmm-2017-0036

Abstract

Aim: We aimed to evaluate the relationships between monocyte-to-high-density lipoprotein ratio (MHR) and lymphocyte-to-monocyte ratio (LMR) and rheumatic mitral valve stenosis (RMVS).

Methodology: A total of 368 patients with mitral stenosis and 80 healthy participants were included. Patients were categorized into two groups in respect to the severity of RMVS as mild-moderate group (mitral valve area ≥1.0 cm²) and severe group (mitral valve area <1.0 cm²).

Results: The MHR (10.6 ± 2.3, 11.6 ± 2.6, 13.8 ± 3.1; p < 0.001) and C-reactive protein levels (control group, nonsevere RMVS and severe RMVS groups 3.4 ± 0.7, 4.4 ± 1.1, 5.2 ± 1.4, respectively; p < 0.001) were significantly increased whereas LMR (4.51 ± 1.3, 3.57 ± 1.3, 3.14 ± 1.4; p < 0.001) levels were significantly decreased in parallel to the severity of mitral stenosis.

Discussion/conclusion: MHR and LMR can be used to predict severity of RMVS.

Keywords: echocardiography; inflammation; lymphocyte-to-monocyte ratio; mitral stenosis; monocyte-to-high-density lipoprotein ratio; rheumatic mitral valve.