Association between Mastication, the Hippocampus, and the HPA Axis: A Comprehensive Review

Int J Mol Sci. 2017 Aug 3;18(8):1687. doi: 10.3390/ijms18081687.

Abstract

Mastication is mainly involved in food intake and nutrient digestion with the aid of teeth. Mastication is also important for preserving and promoting general health, including hippocampus-dependent cognition. Both animal and human studies indicate that mastication influences hippocampal functions through the end product of the hypothalamic-pituitary-adrenal (HPA) axis, glucocorticoid (GC). Epidemiologic studies suggest that masticatory dysfunction in aged individuals, such as that resulting from tooth loss and periodontitis, acting as a source of chronic stress, activates the HPA axis, leading to increases in circulating GCs and eventually inducing various physical and psychological diseases, such as cognitive impairment, cardiovascular disorders, and osteoporosis. Recent studies demonstrated that masticatory stimulation or chewing during stressful conditions suppresses the hyperactivity of the HPA axis via GCs and GC receptors within the hippocampus, and ameliorates chronic stress-induced hippocampus-dependent cognitive deficits. Here, we provide a comprehensive overview of current research regarding the association between mastication, the hippocampus, and HPA axis activity. We also discuss several potential molecular mechanisms involved in the interactions between mastication, hippocampal function, and HPA axis activity.

Keywords: HPA axis; chewing; hippocampus; masticatory dysfunction.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases* / metabolism
  • Cardiovascular Diseases* / pathology
  • Cardiovascular Diseases* / physiopathology
  • Cognitive Dysfunction* / metabolism
  • Cognitive Dysfunction* / pathology
  • Cognitive Dysfunction* / physiopathology
  • Humans
  • Hypothalamo-Hypophyseal System* / metabolism
  • Hypothalamo-Hypophyseal System* / pathology
  • Hypothalamo-Hypophyseal System* / physiopathology
  • Mastication*
  • Osteoporosis* / metabolism
  • Osteoporosis* / pathology
  • Osteoporosis* / physiopathology
  • Periodontitis* / metabolism
  • Periodontitis* / pathology
  • Periodontitis* / physiopathology
  • Pituitary-Adrenal System* / metabolism
  • Pituitary-Adrenal System* / pathology
  • Pituitary-Adrenal System* / physiopathology