Characteristics of a glutamine carrier in skeletal muscle have important consequences for nitrogen loss in injury, infection, and chronic disease

Lancet. 1986 Nov 1;2(8514):1008-12. doi: 10.1016/s0140-6736(86)92617-6.

Abstract

A carrier for glutamine, identified in rat muscle, has properties in terms of kinetics, ion dependence and hormone sensitivity, and effects of endotoxin and branched-chain aminoacids that point to an important function in the control of whole-body aminoacid metabolism. The existence of a link between the size of the glutamine pool in muscle and the rate of muscle protein synthesis raises possibilities for therapeutic interventions to limit protein loss in injury, sepsis, and chronic disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids, Branched-Chain / metabolism
  • Animals
  • Biological Transport
  • Chronic Disease
  • Glutamine / metabolism*
  • Infections / metabolism*
  • Kinetics
  • Muscles / metabolism*
  • Nitrogen / metabolism*
  • Rats
  • Sodium / metabolism
  • Wounds and Injuries / metabolism*

Substances

  • Amino Acids, Branched-Chain
  • Glutamine
  • Sodium
  • Nitrogen