Original article: Platelet-rich plasma with microneedling in androgenetic alopecia along with dermoscopic pre- and post-treatment evaluation

J Cosmet Dermatol. 2018 Jun;17(3):313-318. doi: 10.1111/jocd.12394. Epub 2017 Aug 3.


Background: Platelet-rich plasma has shown beneficial effects in the treatment of androgenic alopecia with its growth factor properties in accelerating the dermal papilla. Dermoscopy is a noninvasive method that allows the in vivo evaluation of microstructures not visible to the naked eye.

Objective: To ascertain the role of platelet-rich plasma (PRP) with microneedling, and to compare the pre- and post-treatment dermoscopic features in androgenetic alopecia. (AGA).

Method: Patients with mild to moderate AGA, aged 18-45 years with Hamilton-Norwood score 1-5 were included in both study and control group. Dermoscopy was performed using Dermlite II hybrid m; 3Gen dermoscope at 10× magnification in polarized mode, and photographs were taken. Those not responding or those not having any new hair growth to conventional therapy for at least 1 year were included. The study group were given autologous platelet-rich plasma injections with microneedling over a period of 3 months at 3 weekly interval. Baseline and post-treatment photographs were taken.

Result: Hair growth started after the first session. The patients' satisfaction was more than 75% in 18 patients, on patients' subjective hair growth assessment scale. In post-PRP-treated patients of AGA, increase in the number of vellus and total hairs, increased hair shaft diameter, and reduction in yellow dots were appreciated after 3 sessions. Hair pull test was negative after treatment in 14 patients (70%).

Conclusion: This study reinforces the importance of dermoscopy in not only aiding in the diagnosis, but also in evaluation of pre- and post-treatment response of AGA.

Keywords: androgenetic alopecia; dermoscopy; hair; microneedling; platelet-rich plasma.

MeSH terms

  • Adult
  • Alopecia / diagnostic imaging*
  • Alopecia / therapy*
  • Dermoscopy*
  • Hair / growth & development*
  • Humans
  • Male
  • Needles
  • Patient Satisfaction
  • Platelet-Rich Plasma*
  • Severity of Illness Index
  • Young Adult