Synthetic genetic circuits in crop plants

Curr Opin Biotechnol. 2018 Feb;49:16-22. doi: 10.1016/j.copbio.2017.07.003. Epub 2017 Jul 31.

Abstract

The love affair between crop breeding and genetics began over a century ago and has continued unabated, from mass selection programs to targeted genome modifications. Synthetic genetic circuits, a recent development, are combinations of regulatory and coding DNA introduced into a crop plant to achieve a desired function. Genetic circuits could accelerate crop improvement, allowing complex traits to be rationally designed and requisite DNA parts delivered directly into a genome of interest. However, there is not yet a standardized pipeline from exploratory laboratory testing to crop trials, and bringing transgenic products to market remains a considerable barrier. We highlight successes so far and future developments necessary to make genetic circuits a viable crop improvement technology over this century.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Crops, Agricultural / genetics*
  • Gene Regulatory Networks*
  • Genetic Engineering
  • Inventions
  • Plant Breeding*
  • Plants, Genetically Modified / genetics