Surveillance in Germline TP53 Mutation Carriers Utilizing Whole-Body Magnetic Resonance Imaging

Mandy L Ballinger; Nicholas J Ferris; Kate Moodie; Gillian Mitchell; Sue Shanley; Paul A James; David M Thomas

doi:10.1001/jamaoncol.2017.1355

Surveillance in Germline TP53 Mutation Carriers Utilizing Whole-Body Magnetic Resonance Imaging

JAMA Oncol. 2017 Dec 1;3(12):1735-1736. doi: 10.1001/jamaoncol.2017.1355.

Authors

Mandy L Ballinger¹, Nicholas J Ferris², Kate Moodie³, Gillian Mitchell⁴, Sue Shanley⁴, Paul A James^{4

5}, David M Thomas¹

Affiliations

¹ Cancer Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
² Monash Biomedical Imaging, Monash University, Clayton, Victoria, Australia
³ Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
⁴ Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
⁵ Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Abstract

This prospective study of surveillance strategies uses a whole-body screening program, including whole-body magnetic resonance imaging, in carriers of germline mutations in TP53.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Female
Germ-Line Mutation*
Heterozygote
Humans
Li-Fraumeni Syndrome / diagnostic imaging*
Li-Fraumeni Syndrome / genetics
Magnetic Resonance Imaging
Male
Middle Aged
Population Surveillance
Prospective Studies
Tumor Suppressor Protein p53 / genetics*
Whole Body Imaging
Young Adult

Substances

TP53 protein, human
Tumor Suppressor Protein p53