Seven-year study of hepatitis B vaccine efficacy in infants from an endemic area (Senegal)

Lancet. 1986 Nov 15;2(8516):1143-5. doi: 10.1016/s0140-6736(86)90543-x.


A booster dose of hepatitis B vaccine was given to 143 children in whom hepatitis B had not developed 1 year after initial vaccination. Over the next six years the incidence of hepatitis B in this group was 1.5% per year compared with 11.5% per year in a similar group of unvaccinated children. In the first 4 years the protective efficacy of the vaccine was 100%, but during the 5th and 6th years it fell to 67%. For maximum protection a second booster is needed, 5 years after the first.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrier State / prevention & control
  • Evaluation Studies as Topic
  • Female
  • Follow-Up Studies
  • Hepatitis B / epidemiology
  • Hepatitis B / immunology
  • Hepatitis B / prevention & control*
  • Hepatitis B Antibodies / analysis
  • Hepatitis B Vaccines
  • Humans
  • Immunization, Secondary*
  • Infant
  • Male
  • Senegal
  • Time Factors
  • Viral Hepatitis Vaccines / administration & dosage*


  • Hepatitis B Antibodies
  • Hepatitis B Vaccines
  • Viral Hepatitis Vaccines