Lower pain and higher muscular strength in immigrant women with vitamin D deficiency following vitamin D treatment

Int J Circumpolar Health. 2017;76(1):1340547. doi: 10.1080/22423982.2017.1340547.

Abstract

Background: Vitamin D deficiency is common among immigrants in the Nordic region. It may lead to osteomalacia with severe musculoskeletal pain. There are reports that vitamin D deficiency without osteomalacia may lead to pain but little is known of the effect of treatment.

Objective: To investigate whether a moderate dose of cholecalciferol and calcium improves strength and pain in a group of vitamin D deficient women.

Design: Twentyfive immigrant women with vitamin D deficiency diagnosed during pregnancy were treated postpartum with a daily dose of 1,600 IU cholecalciferol and 1,000 mg of calcium. They were examined at the start of treatment and again after 3 months of treatement and the results were statistically compared.

Setting: Southern parts of Stockholm.

Main outcome measures: Serum 25-hydroyvitamin D (25(OH)D), serum-parathyroid hormone (PTH), pain measured by a visual analogue scale (VAS), musculoskeletal strength by performance on a chair stand test (seconds), and bone tenderness by pressure algometer (kilo-Pascal).

Results: Following the treatment, the 21 women attending had lowered cm in VAS, improved musculoskeletal strength, - and 25(OH)D levels were normalized.

Conclusions: A moderate dose of vitamin D normalized l vitamin D levels, improved muscular strength and reduced pain in this group of vitamin D deficient immigrant women.

Keywords: Nordic region; Vitamin D; immigrants; muscular strength; musculoskeletal pain.

MeSH terms

  • Adult
  • Dose-Response Relationship, Drug
  • Emigrants and Immigrants / statistics & numerical data*
  • Female
  • Humans
  • Low Back Pain / drug therapy*
  • Middle Aged
  • Muscle Strength*
  • Nutritional Status
  • Sweden
  • Treatment Outcome
  • Vitamin D / administration & dosage*
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / drug therapy*
  • Women's Health
  • Young Adult

Substances

  • Vitamin D
  • 25-hydroxyvitamin D

Grants and funding

This work was supported by MEDA, Sweden, Nycomed, Sweden and Stockholm County Council (ALF).